This report provides an in-depth analysis of the direct costs of cancer, focusing on national government expenditures on cancer-related programs and patient care. It examines healthcare spending on interventions, including personnel, facilities, and medications, using a systematic literature review and a data dictionary to compile relevant datasets. The report introduces the Cancer Risk Factors Index (CRFI) and presents case studies from non-EU countries like Moldova, Montenegro, North Macedonia, and Ukraine, highlighting challenges in data collection.